ABSTRACT
Objective: By taking classical prescription of Gegen Qinlian Decoction (GQD) as the example, this research aims at studying the law of change between the clinical dosage of Chinese medicine and its effect. Methods: The test groups were divided into nine groups according to nine different dosages of GQD (1.65-28.05 g/kg). Each group was given the same dosage for six times. Then the factors of serum protein, blood sugar, insulin, glycated hemoglobins, and insulin resistance index were extracted. Results: Two common factors were extracted and the variance contribution rates were 55.601% and 24.157%, respectively. The first factor could represent blood sugar, glycated hemoglobins, and insulin resistance index, while the second factor could represent serum protein and insulin. Conclusion: Through analyzing the experimental data of GQD in the treatment of diabetes mellitus, it is found that Factor Analysis can achieve better results in eliminating the interference from human factors. Therefore, Factor Analysis is an effective and suitable method for studying the dose-effect relationship of Chinese material medica in clinical therapy.